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亮丙瑞林注射剂联合佳蓉片治疗子宫内膜异位症伴不孕的临床研究

发布时间:2018-09-14 20:55  文章来源:笔耕文化传播
【摘要】:目的观察亮丙瑞林注射剂联合佳蓉片治疗子宫内膜异位症伴不孕的临床疗效及安全性。方法将68例子宫内膜异位症伴不孕患者随机分为对照组34例与试验组34例。2组患者均进行腹腔镜手术治疗。对照组于术后月经复潮后第1~2天予以亮丙瑞林3.75 mg,皮下注射,每4周1次,连续应用6次;试验组在对照组治疗的基础上,于术后予以口服佳蓉片每次0.92 mg,tid,连续用药15 d。比较2组患者的临床疗效、卵泡刺激素(FHS)、黄体生成素(LH)、雌二醇(E2)、睾酮、性激素结合蛋白(SHBG)、妊娠率以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为94.12%(32/34例)和76.47%(26/34例);妊娠率分别为52.94%(18/34例)和26.47%(9/34例),差异均有统计学意义(均P0.05)。治疗后,试验组和对照组的FHS分别为(6.33±0.75),(8.31±0.99)U·L~(-1);LH分别为(5.39±0.59),(6.21±0.86)U·L~(-1);E2分别为(38.02±5.17),(68.39±7.47)pmol·L~(-1);睾酮分别为(0.81±0.90),(1.14±0.17)nmol·L~(-1);SHBG分别为(80.07±9.17),(56.54±7.07)nmol·L~(-1),差异均有统计学意义(均P0.05)。试验组的药物不良反应主要有出汗和经量减少,对照组的药物不良反应主要有出汗、阴道出血和下腹部痛。试验组和对照组的药物不良反应发生率分别为8.82%和11.76%,差异无统计学意义(P0.05)。结论亮丙瑞林注射剂联合佳蓉片治疗子宫内膜异位症伴不孕的临床疗效显著,且不增加药物不良反应的发生率。
[Abstract]:Objective to observe the efficacy and safety of Liangprorelin injection combined with Jiarong tablet in the treatment of endometriosis with infertility. Methods 68 cases of endometriosis with infertility were randomly divided into control group (34 cases) and experimental group (34 cases). The control group was subcutaneously injected with Leprorelin 3.75 mg, subcutaneously every 4 weeks on the 1st day after menorrhagia, and the experimental group was given orally Jiarong tablet for 15 days each time for 15 days on the basis of the treatment in the control group. The clinical efficacy, follicle stimulating hormone (FHS),) luteinizing hormone (LH), estradiol (E2), testosterone, sex hormone binding protein (SHBG),) pregnancy rate and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rate was 94.12% (32 / 34 cases) and 76.47% (26 / 34 cases), the pregnancy rate was 52.94% (18 / 34 cases) and 26.47% (9 / 34 cases) in the experimental group and control group, respectively (P0.05). 娌荤枟鍚,

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