当前位置:主页 > 医学论文 > 生物医学论文 >

多孔仿生骨单元植入物三维打印成型系统开发及实验研究

发布时间:2019-01-09 13:16
【摘要】:理想的人工骨植入物,不仅要求外形与患者的骨缺损部位相符合,还应具有良好的力学性能及合适的生物仿生结构。采用传统加工方法制备人工骨植入物存在耗时长、内部孔隙结构加工困难、无法满足患者个性化需求等问题。利用3D打印技术制备人工骨植入物,不仅有利于实现复杂结构的人工骨植入物快速成型,同时能够精确控制孔隙结构、尺寸及分布,有利于促进骨细胞生长,加快骨修复过程。本课题针对目前骨修复过程中,存在修复植入体结构单一、多孔仿生结构难以加工等问题,通过对多孔结构进行力学仿真分析以及对三维印刷(Three Dimensional Printing, 3DP)打印工艺的研究,提出一种改进的生物陶瓷多孔骨单元三维打印成型系统,主要研究内容如下:选取兔骨小梁缺损部位为研究对象,对其进行图像分割、特征提取,建立骨小梁缺损部位的三维模型。在获取骨小梁缺损部位外轮廓的基础上,通过对植入环境中骨单元的生物力学性能要求进行分析,构建包括“疏松”型、“密质”型、“双层”型和“三层”型在内的四种多孔骨单元内部三维空间构架。再利用布尔运算,建立多孔骨植入物的三维模型。最后,利用有限元分析软件,研究上述多孔骨单元结构特征对其生物力学性能的影响规律。有限元分析结果表明“三层”型结构不仅构造与人体骨骼更为相似,力学性能也更加优越。其次,研究了一种改进的基于3DP工艺的多孔生物陶瓷快速成型方法,并搭建面向骨修复的3DP快速成型实验平台,完成机械结构、运动控制系统及软件设计等。在此基础上,完成多孔骨单元植入物制备并通过相应性能测试,探讨骨单元植入物成型过程中系统参量、模型结构以及烧结工艺对成型骨单元微观外貌和力学性能的影响规律。此研究内容可以为基于3DP工艺的高质量仿生骨骼打印制造的实现提供理论依据,对人工骨骼临床修复有重要的理论和实验意义。
[Abstract]:The ideal artificial bone implants should not only match the shape of bone defect, but also have good mechanical properties and bionic structure. The traditional method of manufacturing artificial bone implants has some problems such as long time consuming, difficult to process internal pore structure, and unable to meet the individual needs of patients. Using 3D printing technology to fabricate artificial bone implants is not only conducive to the rapid prototyping of artificial bone implants with complex structures, but also can accurately control the pore structure, size and distribution, promote the growth of bone cells and speed up the process of bone repair. In order to solve the problems of single implant structure and difficult machining of porous bionic structure in the process of bone repair at present, the mechanical simulation analysis of porous structure and the printing process of 3D printing (Three Dimensional Printing, 3DP are carried out. An improved three dimensional printing system for bioceramic porous bone unit is proposed. The main research contents are as follows: the rabbit trabecular defect is selected as the object of study, and the image segmentation and feature extraction are carried out. A three-dimensional model of bone trabecular defect was established. On the basis of obtaining the external contour of the bone trabecular defect, the biomechanical properties of the bone unit in the implanted environment were analyzed, and the types of "loose" and "dense" were constructed. Four types of porous bone units, including double-layer and three-layer, have three-dimensional structures. Then the three-dimensional model of porous bone implants was established by Boolean operation. Finally, the effects of the structural characteristics of the porous bone elements on the biomechanical properties of the porous bone units are studied by using the finite element analysis software. The results of finite element analysis show that the "three-layer" structure is not only more similar to the human skeleton, but also more superior in mechanical properties. Secondly, an improved rapid prototyping method of porous bioceramics based on 3DP process is studied, and the experimental platform of 3DP rapid prototyping for bone repair is built to complete the mechanical structure, motion control system and software design. On this basis, the porous bone unit implants were prepared and their properties were tested. The effects of system parameters, model structure and sintering process on the microstructure and mechanical properties of bone unit implants were discussed. This research can provide theoretical basis for the realization of high quality bionic bone printing based on 3DP process, and has important theoretical and experimental significance for the clinical restoration of artificial bone.
【学位授予单位】:南京师范大学
【学位级别】:硕士
【学位授予年份】:2017
【分类号】:R318.08;TP391.73

【参考文献】

相关期刊论文 前10条

1 韩曼曼;乌日开西·艾依提;滕勇;张文举;;3D打印技术在足部骨折辅助手术中的应用研究[J];机械设计与制造;2016年10期

2 蒋明辉;蔡立宏;雷青;陈立;陈松;刘堂友;周伟力;;3D打印技术在骨科临床的应用研究及展望[J];中华损伤与修复杂志(电子版);2016年04期

3 郭维安;李爽;高雅洁;闫旭;程倩;;多孔羟基磷灰石生物陶瓷的制备及应用[J];广东化工;2016年14期

4 徐慧芳;冷泠;赵婉雨;;生物陶瓷应用与市场分析[J];新材料产业;2016年01期

5 张海峰;杜子婧;姜闻博;韩冬;;3D打印PLA-HA复合材料与骨髓基质细胞的相容性研究[J];组织工程与重建外科杂志;2015年06期

6 郑云佩;王彦平;强小虎;戴刚;;生物玻璃含量对β-TCP生物陶瓷结构性能的影响[J];兰州交通大学学报;2015年06期

7 刘骥远;吴懋亮;蔡杰;陈军;谢飞;;工艺参数对3D打印陶瓷零件质量的影响[J];上海电力学院学报;2015年04期

8 于灏;;“中国制造2025”下的3D打印[J];新材料产业;2015年07期

9 唐通鸣;张政;邓佳文;钱素艳;李志扬;黄明宇;;基于FDM的3D打印技术研究现状与发展趋势[J];化工新型材料;2015年06期

10 姜杰;朱莉娅;杨建飞;杨继全;;3D打印技术在医学领域的应用与展望[J];机械设计与制造工程;2014年11期

相关会议论文 前1条

1 赖毓霄;李龙;李烨;曹荟娟;王新峦;秦岭;;基于新型3D打印技术的复合活性多孔骨修复支架的研发[A];2015年全国高分子学术论文报告会论文摘要集——主题F-生物医用高分子[C];2015年

相关博士学位论文 前1条

1 王财儒;多孔钛合金股骨头支撑棒的设计制备及其治疗早期股骨头坏死的实验研究[D];第四军医大学;2015年

相关硕士学位论文 前3条

1 曹雪飞;3D打印β-磷酸三钙负载INH、RFP/PLGA缓释微球的生物安全性及成骨作用的研究[D];兰州大学;2016年

2 杨中;基于羟基磷灰石的3D打印和烧结强化人工骨技术研究[D];重庆大学;2015年

3 马健超;3D打印技术在骨结构重建的应用[D];吉林大学;2015年



本文编号:2405678

论文下载
论文发表
教材专著
专利申请


    下载步骤:
    1.微信扫码,备注编号 2405678.
    2.
    点击下载


    本文链接:http://www.bigengculture.com/yixuelunwen/swyx/2405678.html