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隐蔽性高血压患者血浆同型半胱氨酸水平和颈股动脉脉搏波传导速度的关系

发布时间:2019-07-12 08:14
【摘要】:目的观察和分析隐蔽性高血压(MHT)患者血浆同型半胱氨酸(Hcy)和颈股动脉脉搏波传导速度(cfPWV)的水平及其相互关系。方法本研究为横断面研究,纳入202名正常血压者为对照组,MHT患者226例为观察组;两组受试者根据血浆Hcy水平进一步分为高Hcy亚组(Hcy≥10μmol/L)或正常Hcy亚组(Hcy10μmol/L)。检测各研究对象血浆Hcy水平和cfPWV的水平,比较两组间的差异,分析其相互关系。结果 MHT组血浆Hcy和cfPWV水平高于正常血压组。在MHT患者中,高Hcy亚组血浆Hcy和cfPWV水平高于正常Hcy亚组(均P0.05);而在正常血压组人群中,高Hcy亚组与正常Hcy亚组cfPWV的差异无统计学意义(P0.05)。偏相关分析显示,MHT患者血浆Hcy与cfPWV呈正相关(r=0.335,P0.05)。调整混杂因素后,多元回归分析显示,在MHT患者中,血浆Hcy水平是cfPWV的影响因素(B=1.125,P0.05)。结论 MHT患者血浆Hcy与cfPWV呈正相关,血浆Hcy水平是cfPWV的影响因素。
[Abstract]:Objective to observe and analyze the levels of plasma homocysteine (Hcy) and carotid artery pulse wave conduction velocity (cfPWV) in patients with hidden hypertension (MHT) and their relationship. Methods the study was conducted in a cross-section study, including 202 normal blood pressure patients as control group and 226 patients with MHT as observation group. The two groups were further divided into high Hcy subgroup (Hcy10 渭 mol / L) or normal Hcy subgroup (Hcy10 渭 mol / L).) according to plasma Hcy level. The plasma Hcy level and cfPWV level were measured, the differences between the two groups were compared, and the relationship between the two groups was analyzed. Results the levels of plasma Hcy and cfPWV in MHT group were higher than those in normotension group. In MHT patients, plasma Hcy and cfPWV levels in high Hcy subgroup were higher than those in normal Hcy subgroup (P 0.05), but there was no significant difference in cfPWV between high Hcy subgroup and normal Hcy subgroup in normal blood pressure group (P 0.05). Partial correlation analysis showed that plasma Hcy was positively correlated with cfPWV in patients with MHT (r 鈮,

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